Gut-Brain and Probiotics

Our gut health is just as important as our brain health.

Exciting news in the world of brain health! A new study, ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy, was published in 2023 on Science and clearly shows the powerful link between gut health and neurodegeneration.

This study found that manipulating the gut microbiota (the collection of microorganisms in the gut) can reduce tau pathology and neurodegeneration in mice. The effects were seen in both male and female mice, and were more pronounced in mice with a certain genetic trait.

The study also found that gut microbiota manipulation impacts the activity of brain cells called astrocytes and microglia, which play a role in neuroinflammation and tau-mediated neurodegeneration. Additionally, the study suggests that substances produced by gut microorganisms called short-chain fatty acids may be involved in the process.

Overall, the study suggests that targeting the gut microbiome may be a promising approach for preventing or treating Alzheimer's disease and other conditions related to tau protein.
 

The gut and the brain are connected via the gut-brain axis, a communication system that allows the gut microbiome to influence the brain and nervous system. Dysregulation of the gut microbiome has been linked to inflammation, which is known to contribute to the development of Alzheimer's disease.

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Probiotics may help to improve the health of the gut microbiome and reduce inflammation in the brain. Studies have shown that certain probiotic strains can improve cognitive function and reduce the levels of beta-amyloid, a protein that forms plaques in the brains of people with Alzheimer's disease. Probiotics may also reduce neuroinflammation, which is a common feature of neurodegenerative diseases.